Click Rules Manage Rules & Alerts under Home tab. You can create a rule to block out of office reply emails in Outlook. Outlook for Mac works with Microsoft Exchange, Microsoft 365, (including Hotmail and MSN), Gmail, Yahoo Mail, and iCloud Learn more about Microsoft 365 Microsoft 365 is a cloud-based subscription service that brings together premium versions of Word, Excel, PowerPoint, Outlook and OneDrive, with the best tools for the way people. They can be set with a few simple steps: Click on 'Tools' Select 'Out of Office'. Out of office repliies are messages that are sent back to people who send you E-mail messages, generally to let them know that you are out of the office that day. Setting out of office autoreplies on Outlook for Mac. Out Of Office Greyed Out In Outlook For Mac.For Microsoft Office Outlook 2016, 20-You can follow the below steps to set an Out of Office Reply in Outlook, if you are using any of the above Outlook settings. Related Post: How to Set up email in the Outlook for Android app.